There are a few skincare products that have genuinely earned a permanent spot on my vanity, and Shiseido’s Ultimune Power Infusing Serum is one of them. Now newly reformulated, this cult-favourite serum is better than ever — and after using it consistently over the past few weeks, I can confidently say it lives up to the hype.

What It Does
The Ultimune Power Infusing Serum strengthens your skin’s natural defences, improve resilience, and boost hydration. It’s packed with Shiseido’s ImuGenerationRED Technology™, a blend of antioxidant-rich ingredients like Reishi mushroom extract and iris root extract that work together to protect against daily stressors and pollution while enhancing skin’s overall vitality.
What I appreciate most about this serum is that it’s not just a quick fix. It’s one of those products that gradually improves your skin’s texture, radiance, and suppleness over time. My complexion feels smoother, looks more even, and seems to bounce back faster from late nights and environmental stress.
Texture & Application
The texture is where this serum really shines for me. It’s silky, lightweight, and absorbs quickly without leaving any greasy or sticky residue. It layers beautifully under moisturiser, SPF, or makeup — making it easy to slot into both your morning and evening routines.
A couple of pumps is all you need. I apply it right after cleansing and before any heavier treatments or creams, and it instantly makes my skin feel hydrated and calm.

Visible Results
Since adding the new Ultimune back into my routine, I’ve noticed my skin looks fresher, smoother, and more balanced. It’s helped soften the appearance of fine lines, and my skin feels more resilient overall. I’ve even had a few “you’re glowing” compliments lately, which I’m definitely crediting to this serum.
Final Thoughts
If you’re looking for a well-rounded, reliable serum that boosts hydration, strengthens skin, and enhances radiance, Shiseido Ultimune Power Infusing Serum is one to invest in. It’s the kind of product that quietly works in the background, steadily improving your skin’s health and resilience day after day. It’s gentle, effective, and one I’ll keep repurchasing. It is said that the ultimune serume works on the parts of skin in need while maintaining balance.
I have been using this serum under the moisturizers from the Shiseido Future Solution LX range – Shiseido Future Solution LX Total Protective Cream for daytime (detailed review here), and Shiseido Future Solution LX Total Regenerating Cream for nighttime (detailed review here). And always using sun care during the day, my go-to is Shiseido Ultra Sun Protector Lotion SPF 50+ (detailed review here).
Where To Buy It?
New Shiseido Ultimune Power Infusing Serum 4.0 is available at:
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